What is the best modern desktop GUI framework for python

1. PyQt: PyQt is a comprehensive set of Python bindings for the Qt application framework and runs on all platforms supported by Qt, including Windows, OS X, Linux, iOS, and Android. PyQt is a mature and powerful framework that offers a wide range of features, including support for widgets, layouts, signals and slots, and more.
2. Kivy: Kivy is an open-source Python framework for creating cross-platform mobile and desktop applications. It is based on the OpenGL ES 2 graphics engine and uses modern software design patterns, such as event-driven programming and the Model-View-Controller (MVC) architecture. Kivy is known for its fast performance and responsive user interface.
3. PyGTK: PyGTK is a set of Python bindings for the GTK+ application framework, which is widely used on Linux and other Unix-like platforms. PyGTK provides a range of features for building graphical user interfaces, including support for widgets, layouts, signals and slots, and more.
4. PySide: PySide is a set of Python bindings for the Qt application framework that is developed and maintained by the Qt Project. PySide is similar to PyQt, but has a different license and is available under the LGPL.

Overall, the best modern desktop GUI framework for Python will depend on your specific needs and preferences. Each of the frameworks mentioned above has its own strengths and weaknesses, and it may be worth evaluating each one to determine which is the best fit for your project.